High intratumoural heterogeneity of endometrial cancer revealed

Source: www.immedicohospitalario.es

Spanish researchers have just published a study that unravels the high intratumoural heterogeneity present in the different subtypes of endometrial cancer (serous and endometrioid) by analysing the exome of various regions of the primary tumour and its metastases.

The study, published in ‘Oncogene’, has been carried out by the Autonomous University researchers Alba Mota and Sara Oltra, who have received grants from the Spanish Association Against Cancer and the CIBERONC group coordinated by Gema Moreno-Bueno with the collaboration of two other CIBERONC groups led by Xavier Matias Guiu of the Institute for Biomedical Research of Lleida, Pifarre Foundation, and Rafael López, University Hospital Complex Santiago.

This analysis has clarified the different patterns of tumour evolution of endometrial cancer that could have relevance in its metastatic dissemination and clinical behaviour. In addition, this study has characterised for the first time the genomic alterations of a subtype of endometrial cancer known as ambiguous, with an adverse clinical prognosis, allowing the genomic information obtained to be used to establish a personalised treatment for this tumour subtype, which has been validated in preclinical PDX models.

“Understanding the genetic basis of endometrial cancer is considered the first step in the personalised design of treatment for patients with this type of cancer,” concludes Dr Moreno-Bueno, who has been supported in the project by the Spanish Association Against Cancer (AECC).

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